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Future research should focus on developing strategies for selective targeting to minimize effects on normal tissues, understanding mechanisms of resistance and ways to overcome them, and optimizing combination therapies with chemotherapy, radiotherapy, or immunotherapy to enhance efficacy

10.3389/fnut.2025.1504831 34 Lpez-SnchezC.de AndrsF.ZougaghM.Ros

This activation leads to enhanced dopamine synthesis and release, potentially compensating for the loss of dopaminergic neurons in Parkinsons disease

While both compounds improve these metrics, the magnitude of change in retatrutide trials has led some researchers to suggest it may provide a more potent "reset" of metabolic syndrome markers